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¹Department of Ophthalmology, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Türkiye
²Department of Ophthalmology, Kırşehir Training and Research Hospital, Kırşehir, Türkiye DOI : 10.37844/TJ-CEO.2025.20.38 A 64-year-old man underwent anterior vitrectomy for pupil dilation and photophobia due to vitreous prolapse in his left eye. The surgery was completed without complications. At the end of the surgery, intracameral cefuroxime was injected for prophylaxis. Immediately after the injection, the patient developed dry mouth and itching all over his body. He was immediately treated with intravenous fluids, intramuscular histamine antagonists and intravenous corticosteroids. His condition improved rapidly. His family confirmed that he had a drug allergy that had developed after previous oral cefuroxime intake. Keywords : Cefuroxime, drug hypersensitivity, vitrectomy, anaphylaxis, intracameral injection